Depends on what you want to do.
The expert modders (Click, Philetbabe, Madiaba, am I missing anyone?) made a bunch of custom AI's that accomodate a lot of weird weapon types. To name a few things you can do with it; multiple weapons that fire seperately, FrenZy style hammers, pincers and crushers that sort of work, axes mounted on rotating turrets, and srimechs.